Transfusion‐related immunomodulation (TRIM) in the intensive care unit (ICU) is difficult to
define and likely represents a complicated set of physiologic responses to transfusion …

The early transfusion of plasma is important to ensure optimal survival of patients with
traumatic hemorrhage. In military and remote or austere civilian settings, it may be …

Damage control resuscitation (DCR) is a strategy for resuscitating patients from hemorrhagic
shock to rapidly restore homeostasis. Efforts are focused on blood product transfusion with …

Traumatic hemorrhage is the leading cause of preventable death after trauma. Early
transfusion of plasma and balanced transfusion have been shown to optimize survival …

Severely injured patients with hemorrhagic shock can develop endothelial dysfunction,
systemic inflammation, and coagulation disturbances collectively known as the …

Summary Background: Extracellular vesicles (EVs) in blood products are potential effectors
of inflammation and coagulation after transfusion. The aim of this study was to assess the …

The clinical state of shock constitutes a relative or absolute deficiency of circulating volume
for adequate oxygen delivery to meet the metabolic demands. 1 Although shock states differ …

Background Hemorrhage is a leading cause of preventable death in civilian and military
trauma. Freeze‐dried plasma is promising for hemostatic resuscitation in remote prehospital …

Transfusion of red cell concentrates (RCCs) is associated with increased risk of adverse
outcomes that may be affected by different blood manufacturing methods and the presence …

Factor X deficiency is a rare coagulation disorder that can be hereditary or acquired. The
typology and severity of the associated bleeding symptoms are highly heterogeneous …