Cachexia, a systemic wasting condition, is considered a late consequence of diseases,
including cancer, organ failure, or infections, and contributes to significant morbidity and …

Interleukin-6 is a pleiotropic cytokine regulating different tissues and organs in diverse and
sometimes discrepant ways. The dual and sometime hermetic nature of IL-6 action has been …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Global rates of obesity continue to rise and are necessarily the consequence of a long-term
imbalance between energy intake and energy expenditure. This is the result of an …

Background Cachexia is frequent, deadly, and untreatable for patients with pancreatic ductal
adenocarcinoma (PDAC). The reproductive hormone and cytokine Activin is a mediator of …

Habitual endurance exercise training is associated with multisystemic metabolic adaptations
that lower the risk of inactivity-associated disorders such as obesity and type 2 diabetes …

Abstract Purpose of Review Cachexia, a feature of cancer and other chronic diseases, is
marked by progressive weight loss and skeletal muscle wasting. This review aims to …

Cancer cachexia is a kind of whole-body metabolic disorder syndrome accompanied by
severe wasting of muscle tissue in which cancer exosomes may be involved. Analysis of …

Only in recent years, thanks to a precision medicine-based approach, have treatments
tailored to the sex of each patient emerged in clinical trials. In this regard, both striated …

Cachexia, the unintentional loss of body weight, is prevalent in many cancer types, and the
associated skeletal muscle mass depletion increases patient morbidity and mortality. While …