Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Background Drugs prescribed for psychiatric disorders in adolescence should be studied
very extensively since they can affect developing and thus highly plastic brain differently …

The global prevalence of depression is high during childbearing. Due to the associated risks
to the mother and baby, the selective serotonin reuptake inhibitor fluoxetine (FLX) is often …

Studies about the pathogenesis of mood disorders have consistently shown that multiple
factors, including genetic and environmental, play a crucial role on their development and …

Background The release of zinc from glutamatergic terminals in the hippocampal CA3
region can activate postsynaptic GPR39 receptors and regulate cognition and depression …

During the peripartum period, women are at an increased risk to develop perinatal distress,
presenting as symptoms of depression and/or anxiety. Yet, due to practical and ethical …

Depression is associated with uncontrolled diabetes, which indicates a lack of insulin effect,
yet the role of the insulin receptor in mediating depression is not clearly established …

Chronic stress is associated with impairment of synapse plasticity in hippocampus and
cognitive dysfunction in rodent and human. Notably, corticosterone (CORT) is believed to …

Depression usually emerges during adolescence, is significantly more frequent in women,
and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies …

Juvenile depression is of great concern with only limited treatment currently approved.
Delayed onset of action, low remission and high relapse rates, and potential long-lasting …