Advances in the development of new biomarkers for Alzheimer's disease

TO Klyucherev, P Olszewski, AA Shalimova… - Translational …, 2022 - Springer
Alzheimer's disease (AD) is a complex, heterogeneous, progressive disease and is the most
common type of neurodegenerative dementia. The prevalence of AD is expected to increase …

microRNA dysregulation in neurodegenerative diseases: A systematic review

CA Juźwik, SS Drake, Y Zhang, N Paradis-Isler… - Progress in …, 2019 - Elsevier
While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

[HTML][HTML] A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population

JM Delgado-Saborit, V Guercio, AM Gowers… - Science of the Total …, 2021 - Elsevier
Dementia is arguably the most pressing public health challenge of our age. Since dementia
does not have a cure, identifying risk factors that can be controlled has become paramount …

Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Emergence of extracellular vesicles as “liquid biopsy” for neurological disorders: boom or bust

A Kumar, MA Nader, G Deep, A Baker - Pharmacological reviews, 2024 - Elsevier
Extracellular vesicles (EVs) have emerged as an attractive liquid biopsy approach in the
diagnosis and prognosis of multiple diseases and disorders. The feasibility of enriching …

[HTML][HTML] Alzheimer's disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs

AR Monteiro, DJ Barbosa, F Remião, R Silva - Biochemical Pharmacology, 2023 - Elsevier
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases that
affect millions of people worldwide, with both prevalence and incidence increasing with age …

An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders

NJ Ashton, A Hye, AP Rajkumar, A Leuzy… - Nature Reviews …, 2020 - nature.com
Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Role of nuclear factor kappa B (NF-κB) signalling in neurodegenerative diseases: an mechanistic approach

S Singh, TG Singh - Current Neuropharmacology, 2020 - ingentaconnect.com
A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

What genes are differentially expressed in individuals with schizophrenia? A systematic review

AK Merikangas, M Shelly, A Knighton, N Kotler… - Molecular …, 2022 - nature.com
Schizophrenia is a severe, complex mental disorder characterized by a combination of
positive symptoms, negative symptoms, and impaired cognitive function. Schizophrenia is …

miR-212 and miR-132 are downregulated in neurally derived plasma exosomes of Alzheimer's patients

DJ Cha, D Mengel, M Mustapic, W Liu… - Frontiers in …, 2019 - frontiersin.org
It was recently discovered that brain cells release extracellular vesicles (EV) which can pass
from brain into blood. These findings raise the possibility that brain-derived EV's present in …