Metastasis is the complex process by which primary tumor cells migrate and establish
secondary tumors in an adjacent or distant location in the body. Early detection of metastatic …

Despite significant clinical progress in cell and gene therapies, maximizing protein
expression in order to enhance potency remains a major technical challenge. Here, we …

Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for
clinical application as a safe, efficient, noninvasive tool for visualization of various cellular …

Coronary artery venous bypass grafts typically fail because of atherosclerosis driven by lipid
and macrophage accumulation. Therapy for vein-graft atherosclerosis is limited to statin …

Expression of atheroprotective genes in the blood vessel wall is potentially an effective
means of preventing or reversing atherosclerosis. Development of this approach has been …

It is very important to develop an effective, specific, and robust expression cassette that
ensures a high level of expression in the mammary glands. In this study, we designed and …

Transduction of endothelial cells (EC) with a vector that expresses apolipoprotein AI (APOAI)
reduces atherosclerosis in arteries of fat-fed rabbits. However, the effects on atherosclerosis …

Our long-term goal is to prevent or reverse atherosclerosis by delivering gene therapy from
stably transduced endothelial cells (EC). We previously reported that EC-directed gene …

Vascular gene therapy could potentially complement or replace current therapies for human
atherosclerosis, while avoiding their side effects. However, development of vascular gene …

Objective—Vascular gene transfer is a powerful tool for investigating and treating vascular
diseases; however, its utility is limited by brevity of transgene expression and vector …