The synapse as a treatment avenue for Alzheimer's Disease

L Peng, I Bestard-Lorigados, W Song - Molecular psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder with devastating symptoms,
including memory impairments and cognitive deficits. Hallmarks of AD pathology are …

The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives

L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …

Targeting NLRP3 inflammasome for neurodegenerative disorders

J Yao, Z Wang, W Song, Y Zhang - Molecular Psychiatry, 2023 - nature.com
Neuroinflammation is a key pathological feature in neurological diseases, including
Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing …

Factors that influence adult neurogenesis as potential therapy

B Shohayeb, M Diab, M Ahmed, DCH Ng - Translational …, 2018 - Springer
Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside
within distinct regions of the brain. This phenomenon was first described over 50 years ago …

Involvement of adult hippocampal neurogenesis in learning and forgetting

S Yau, A Li, KF So - Neural plasticity, 2015 - Wiley Online Library
Adult hippocampal neurogenesis is a process involving the continuous generation of
newborn neurons in the hippocampus of adult animals. Mounting evidence has suggested …

A new chapter in the field of memory: adult hippocampal neurogenesis

M Koehl, DN Abrous - European Journal of Neuroscience, 2011 - Wiley Online Library
Understanding the cellular mechanisms underlying learning and memory is a major
challenge in neurobiology. Structural and functional changes occurring in the hippocampus …

Targeting DNA methylation in the adult brain through diet

J Allison, A Kaliszewska, S Uceda, M Reiriz, N Arias - Nutrients, 2021 - mdpi.com
Metabolism and nutrition have a significant role in epigenetic modifications such as DNA
methylation, which can influence gene expression. Recently, it has been suggested that …

Neuroepigenetics of ageing and neurodegeneration-associated dementia: an updated review

FA Mir, A Amanullah, BP Jain, Z Hyderi… - Ageing Research …, 2023 - Elsevier
Gene expression is tremendously altered in the brain during memory acquisition, recall, and
forgetfulness. However, non-genetic factors, including environmental elements, epigenetic …

Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease

SF Kazim, K Iqbal - Molecular neurodegeneration, 2016 - Springer
Alzheimer's disease (AD) is an incurable and debilitating chronic progressive
neurodegenerative disorder which is the leading cause of dementia worldwide. AD is a …

Interaction between neurogenesis and hippocampal memory system: new vistas

DN Abrous, JM Wojtowicz - Cold Spring Harbor …, 2015 - cshperspectives.cshlp.org
During the last decade, the questions on the functionality of adult neurogenesis have
changed their emphasis from if to how the adult-born neurons participate in a variety of …