Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

In 1988, the first contrast agent specifically designed for magnetic resonance imaging (MRI),
gadopentetate dimeglumine (Magnevist®), became available for clinical use. Since then, a …

We report a multicenter, randomized, double-blind, placebo-controlled trial of interferon beta-
lb (IFNB) in 372 ambulatory patients with relapsing-remitting multiple sclerosis (MS). Entry …

Background Previous trials of interferon β in multiple sclerosis (MS) have shown efficacy, but
the degree of clinical benefit remains uncertain, and the optimum dose is not known. We …

Objective: To determine whether diffusion tensor imaging (DTI) can detect structural
changes in normal-appearing white matter, and to distinguish between plaques of different …

Previous research has suggested that cerebral lesions observed on magnetic resonance
imaging (MRI) of MS patients are clinically “silent.” We examined the validity of this assertion …

White matter microstructural changes during the first three years of healthy brain
development are characterized using two different models developed for limited clinical …

Activation of innate immune cells and other compartmentalized inflammatory cells in the
brains and spinal cords of people with relapsing–remitting multiple sclerosis (MS) and …

Multiple sclerosis (MS) is a relatively common, chronic progressive neurological illness
affecting individuals primarily in the third and fourth decades of life. Autopsy studies indicate …

We reviewed the MRIs of 49 asymptomatic volunteers (age range, 31 to 77 years) and of 50
MS patients (age range, 14 to 63) for areas of increased signal (AIS) and features …