MicroRNA regulation of atherosclerosis

MW Feinberg, KJ Moore - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …

MicroRNAs in cardiovascular disease

T Barwari, A Joshi, M Mayr - Journal of the American College of Cardiology, 2016 - jacc.org
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of
gene expression. More than 1,000 miRNAs are encoded in the human genome. In this …

Circular RNA CircMAP3K5 acts as a MicroRNA-22-3p sponge to promote resolution of intimal hyperplasia via TET2-mediated smooth muscle cell differentiation

Z Zeng, L Xia, S Fan, J Zheng, J Qin, X Fan, Y Liu… - Circulation, 2021 - Am Heart Assoc
Background: Aberrant expression of circular RNA contributes to human diseases. Circular
RNAs regulate gene expression by sequestering specific microRNAs. In this study, we …

miRNAs orchestration of salivary gland cancer-Particular emphasis on diagnosis, progression, and drug resistance

AA El-Husseiny, NM Abdelmaksoud… - … -Research and Practice, 2023 - Elsevier
Cancer of the salivary glands is one of the five major types of head and neck cancer. Due to
radioresistance and a strong propensity for metastasis, the survival rate for nonresectable …

MicroRNAs in stress signaling and human disease

JT Mendell, EN Olson - Cell, 2012 - cell.com
Disease is often the result of an aberrant or inadequate response to physiologic and
pathophysiologic stress. Studies over the last 10 years have uncovered a recurring …

Identifying circulating microRNAs as biomarkers of cardiovascular disease: a systematic review

R Navickas, D Gal, A Laucevičius… - Cardiovascular …, 2016 - academic.oup.com
The aim of the present study is to identify microRNAs (miRs) with high potential to be used
as biomarkers in plasma and/or serum to clinically diagnose, or provide accurate prognosis …

Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence

JC Wang, M Bennett - Circulation research, 2012 - Am Heart Assoc
Atherosclerosis is classed as a disease of aging, such that increasing age is an independent
risk factor for the development of atherosclerosis. Atherosclerosis is also associated with …

An update on the phenotypic switching of vascular smooth muscle cells in the pathogenesis of atherosclerosis

F Zhang, X Guo, Y Xia, L Mao - Cellular and Molecular Life Sciences, 2022 - Springer
Vascular smooth muscle cells (VSMCs) are involved in phenotypic switching in
atherosclerosis. This switching is characterized by VSMC dedifferentiation, migration, and …

MicroRNAs in development and disease

D Sayed, M Abdellatif - Physiological reviews, 2011 - journals.physiology.org
MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

The biological functions of miRNAs: lessons from in vivo studies

JA Vidigal, A Ventura - Trends in cell biology, 2015 - cell.com
Despite their clear importance as a class of regulatory molecules, pinpointing the relevance
of individual miRNAs has been challenging. Studies querying miRNA functions by …