In addition to their classical roles as detergents to aid in the process of digestion, bile acids
have been identified as important signaling molecules that function through various nuclear …

Chemical cues and pheromones guide decisions in organisms throughout the animal
kingdom. The neurobiology, function, and evolution of olfaction are particularly well …

Sea lamprey invaded the Laurentian Great Lakes above Lake Ontario in the 1900s, and
were a factor in the collapse of several major fish stocks. Whether the species is native to …

Bile salts are potent olfactory stimuli in fishes; however the biological functions driving such
sensitivity remain poorly understood. We provide an integrative review of bile salts as …

Lampreys have long been the food of kings. They have been highly appreciated by the
English monarchy and upper classes since medieval times, and long before that, by the …

This review is based upon an invited lecture for the 52nd Annual Meeting of the British
Association of Paediatric Surgeons, July 2015. The aetiology of biliary atresia (BA) is at best …

Biliary atresia (BA) is a progressive fibro-obliterative process with a variable degree of
inflammation involving the hepatobiliary system. Its consequences are incalculable for the …

Background MicroRNAs (miRNAs) are small regulatory molecules which post-
transcriptionally regulate mRNA stability and translation. Several microRNAs have received …

The sea lamprey (Petromyzon marinus) is a genetically programmed animal model for
biliary atresia, as it loses its bile ducts and gallbladder during metamorphosis. However, in …

Background In vertebrates, bile salts are primarily synthesized in the liver and secreted into
the intestine where they aid in absorption of dietary fats. Small amounts of bile salts that are …