Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

Prevalent in nature, protein oligomers play critical roles both physiologically and
pathologically. The multimeric nature and conformational transiency of protein oligomers …

Type A γ-aminobutyric acid receptors (GABAARs) are inhibitory pentameric ligand-gated ion
channels in the brain. Many anesthetics and neurosteroids act through binding to the …

Heteromeric nicotinic ACh receptors (nAChRs) were thought to have two orthodox agonist‐
binding sites at two α/β subunit interfaces. Highly selective ligands are hard to develop by …

Considerable progress has been made in recent years towards the identification and
characterisation of novel subtype-selective modulators of nicotinic acetylcholine receptors …

The precise mechanism by which propofol enhances GABAergic transmission remains
unclear, but much progress has been made regarding the underlying structural and dynamic …

The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating
inhibitory transmission in the nervous system. Its transmembrane domain (TMD) is the target …

The transduction of extracellular chemical signals into intracellular events relies on the
communication between neighboring domains of membrane receptors. In the particular case …

Structural rearrangements underlying functional transitions of pentameric ligand-gated ion
channels (pLGICs) are not fully understood. Using 19 F nuclear magnetic resonance and …

The role of the outermost transmembrane α-helix in both the maturation and function of the
prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was examined by Ala …