Urolithins: a comprehensive update on their metabolism, bioactivity, and associated gut microbiota

R García‐Villalba, JA Giménez‐Bastida… - Molecular nutrition & …, 2022 - Wiley Online Library
Urolithins, metabolites produced by the gut microbiota from the polyphenols ellagitannins
and ellagic acid, are discovered by the research group in humans almost 20 years ago …

Urine metabolites and bioactive compounds from functional food: applications of liquid chromatography mass spectrometry

ES Ong - Critical Reviews in Analytical Chemistry, 2024 - Taylor & Francis
Bioactive compounds in functional foods, medicinal plants and others are considered
attractive value-added molecules based on their wide range of bioactivity. It is clear that an …

The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: A randomized controlled trial

E Rinott, AY Meir, G Tsaban, H Zelicha, A Kaplan… - Genome medicine, 2022 - Springer
Background Previous studies have linked the Mediterranean diet (MED) with improved
cardiometabolic health, showing preliminary evidence for a mediating role of the gut …

The effect of high-polyphenol Mediterranean diet on visceral adiposity: the DIRECT PLUS randomized controlled trial

H Zelicha, N Kloting, A Kaplan, A Yaskolka Meir… - BMC medicine, 2022 - Springer
Background Mediterranean (MED) diet is a rich source of polyphenols, which benefit
adiposity by several mechanisms. We explored the effect of the green-MED diet, twice …

[HTML][HTML] The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: The Dietary Intervention …

A Kaplan, H Zelicha, AY Meir, E Rinott… - The American Journal of …, 2022 - Elsevier
Background The effect of diet on age-related brain atrophy is largely unproven. Objectives
We aimed to explore the effect of a Mediterranean diet (MED) higher in polyphenols and …

The effect of polyphenols on DNA methylation-assessed biological age attenuation: the DIRECT PLUS randomized controlled trial

A Yaskolka Meir, M Keller, A Hoffmann, E Rinott… - BMC medicine, 2023 - Springer
Background Epigenetic age is an estimator of biological age based on DNA methylation; its
discrepancy from chronologic age warrants further investigation. We recently reported that …

[HTML][HTML] A polyphenol-rich green Mediterranean diet enhances epigenetic regulatory potential: the DIRECT PLUS randomized controlled trial

A Hoffmann, AY Meir, T Hagemann, P Czechowski… - Metabolism, 2023 - Elsevier
Background The capacity of a polyphenol-enriched diet to modulate the epigenome in vivo
is partly unknown. Given the beneficial metabolic effects of a Mediterranean (MED) diet …

Terrestrial and floating aquatic plants differ in acclimation to light environment

M López-Pozo, WW Adams III, SK Polutchko… - Plants, 2023 - mdpi.com
The ability of plants to respond to environmental fluctuations is supported by acclimatory
adjustments in plant form and function that may require several days and development of a …

[HTML][HTML] Glycemic control contributes to the neuroprotective effects of Mediterranean and green-Mediterranean diets on brain age: the DIRECT PLUS brain-magnetic …

D Pachter, A Kaplan, G Tsaban, H Zelicha… - The American Journal of …, 2024 - Elsevier
Background We recently reported that Mediterranean (MED) and green-MED diets
significantly attenuated age-related brain atrophy by∼ 50% within 18 mo. Objective The …

NMR metabolomics reveal urine markers of microbiome diversity and identify benzoate metabolism as a mediator between high microbial alpha diversity and …

J Hertel, D Fässler, A Heinken, FU Weiß, M Rühlemann… - Metabolites, 2022 - mdpi.com
Microbial metabolites measured using NMR may serve as markers for physiological or
pathological host–microbe interactions and possibly mediate the beneficial effects of …