The biology of pediatric acute megakaryoblastic leukemia
TA Gruber, JR Downing - Blood, The Journal of the American …, 2015 - ashpublications.org
Acute megakaryoblastic leukemia (AMKL) comprises between 4% and 15% of newly
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
diagnosed pediatric acute myeloid leukemia patients. AMKL in children with Down …
Red blood cells as potential repositories of microRNAs in the circulatory system
L Sun, Y Yu, B Niu, D Wang - Frontiers in genetics, 2020 - frontiersin.org
The amount of erythrocyte-derived microRNAs (miRNAs) represents the majority of miRNAs
expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red …
expressed in whole blood. miR-451, miR-144, and miR-486, which are abundant in red …
Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming
Y Liang, H He, W Wang, H Wang, S Mo, R Fu, X Liu… - Molecular Cancer, 2022 - Springer
Background Multiple myeloma (MM) is a heterogeneous disease with different patterns of
clonal evolution and a complex tumor microenvironment, representing a challenge for …
clonal evolution and a complex tumor microenvironment, representing a challenge for …
MicroRNA-486 regulates normal erythropoiesis and enhances growth and modulates drug response in CML progenitors
LS Wang, L Li, L Li, S Chu, KD Shiang… - Blood, The Journal …, 2015 - ashpublications.org
MicroRNAs (miRNAs) are key regulators of hematopoietic cell differentiation and may
contribute to altered growth of leukemic stem cells. Using microarray-based miRNA profiling …
contribute to altered growth of leukemic stem cells. Using microarray-based miRNA profiling …
A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes
JF Doss, DL Corcoran, DD Jima, MJ Telen, SS Dave… - BMC genomics, 2015 - Springer
Background Human erythrocytes are terminally differentiated, anucleate cells long thought
to lack RNAs. However, previous studies have shown the persistence of many small-sized …
to lack RNAs. However, previous studies have shown the persistence of many small-sized …
Clinical and biological aspects of myeloid leukemia in Down syndrome
AC Boucher, KJ Caldwell, JD Crispino, JE Flerlage - Leukemia, 2021 - nature.com
Children with Down syndrome are at an elevated risk of leukemia, especially myeloid
leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal …
leukemia (ML-DS). This malignancy is frequently preceded by transient abnormal …
[HTML][HTML] Down syndrome and leukemia: insights into leukemogenesis and translational targets
MK Mateos, D Barbaric, SA Byatt, R Sutton… - Translational …, 2015 - ncbi.nlm.nih.gov
Children with Down syndrome (DS) have a significantly increased risk of childhood
leukemia, in particular acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic …
leukemia, in particular acute megakaryoblastic leukemia (AMKL) and acute lymphoblastic …
MicroRNA profiling of neurons generated using induced pluripotent stem cells derived from patients with schizophrenia and schizoaffective disorder, and 22q11. 2 Del
We are using induced pluripotent stem cell (iPSC) technology to study neuropsychiatric
disorders associated with 22q11. 2 microdeletions (del), the most common known …
disorders associated with 22q11. 2 microdeletions (del), the most common known …
A Sox2: miR-486-5p axis regulates survival of GBM cells by inhibiting tumor suppressor networks
H Lopez-Bertoni, IS Kotchetkov, N Mihelson, B Lal… - Cancer research, 2020 - AACR
Glioblastoma multiforme (GBM) and other solid malignancies are heterogeneous and
contain subpopulations of tumor cells that exhibit stem-like features. Our recent findings …
contain subpopulations of tumor cells that exhibit stem-like features. Our recent findings …
Serum miR-486-5p as a diagnostic marker in cervical cancer: with investigation of potential mechanisms
C Li, X Zheng, W Li, F Bai, J Lyu, QH Meng - BMC cancer, 2018 - Springer
Background Around the world, cervical cancer is the fourth most common cancer among
women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as …
women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as …