Comprehensive analysis of lipids in biological systems by liquid chromatography-mass spectrometry

T Cajka, O Fiehn - TrAC Trends in Analytical Chemistry, 2014 - Elsevier
Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Ms-based lipidomics of human blood plasma: A community-initiated position paper to develop accepted guidelines1

B Burla, M Arita, M Arita, AK Bendt… - Journal of lipid …, 2018 - ASBMB
Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in
hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) …

An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of blood plasma intact lipids

MA Surma, R Herzog, A Vasilj, C Klose… - European Journal of …, 2015 - Wiley Online Library
Blood plasma has gained protagonism in lipidomics studies due to its availability,
uncomplicated collection and preparation, and informative readout of physiological status. At …

Recommendations and best practices for standardizing the pre-analytical processing of blood and urine samples in metabolomics

R González-Domínguez, Á González-Domínguez… - Metabolites, 2020 - mdpi.com
Metabolomics can be significantly influenced by a range of pre-analytical factors, such as
sample collection, pre-processing, aliquoting, transport, storage and thawing. This therefore …

Recent advances in sample preparation techniques to overcome difficulties encountered during quantitative analysis of small molecules from biofluids using LC-MS …

C Bylda, R Thiele, U Kobold, DA Volmer - Analyst, 2014 - pubs.rsc.org
Liquid chromatography-mass spectrometry analysis of small molecules from biofluids
requires sensitive and robust assays. Because of the very complex nature of many biological …

Analytical methods in lipidomics and their applications

M Li, L Yang, Y Bai, H Liu - Analytical chemistry, 2014 - ACS Publications
As a branch of metabolomics, lipidomics is aimed at full analysis of lipid species and their
biological roles with respect to health and diseases and has attracted increasing attention of …

Reviewing the metabolome coverage provided by LC-MS: Focus on sample preparation and chromatography-A tutorial

M Roca, MI Alcoriza, JC Garcia-Cañaveras… - Analytica Chimica Acta, 2021 - Elsevier
Metabolomics has become an invaluable tool for both studying metabolism and biomarker
discovery. The great technical advances in analytical chemistry and bioinformatics have …

Human plasma stability during handling and storage: impact on NMR metabolomics

J Pinto, MRM Domingues, E Galhano, C Pita… - Analyst, 2014 - pubs.rsc.org
This work contributes to fill in some existing gaps in the knowledge of human plasma
degradability during handling and storage, a paramount issue in Nuclear Magnetic …

Recent developments in sample-pretreatment techniques for mass spectrometry-based metabolomics

RJ Raterink, PW Lindenburg, RJ Vreeken… - TrAC Trends in …, 2014 - Elsevier
Metabolomics is one of the most rapidly evolving of the omics sciences. For phenotyping
individuals, it offers a promising platform that is needed for breakthroughs in biomedical and …