Neurons have more extended and complex shapes than other cells and consequently face a
greater challenge in distributing and maintaining mitochondria throughout their arbors …

Rodent models of nerve injury have increased our understanding of peripheral nerve
regeneration, but clinical applications have been scarce, partly because such models do not …

Axon degeneration is a prominent early feature of most neurodegenerative disorders and
can also be induced directly by nerve injury in a process known as Wallerian degeneration …

Intense noise exposure causes hearing loss by inducing degeneration of spiral ganglia
neurites that innervate cochlear hair cells. Nicotinamide adenine dinucleotide (NAD+) …

In spite of tremendous research efforts we have not yet achieved two of our principal
therapeutic goals in the treatment of Parkinson's disease (PD), to prevent its onward …

Brain computation is metabolically expensive and requires the supply of significant amounts
of energy. Mitochondria are highly specialized organelles whose main function is to …

Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding
process. Extrinsic insults and intrinsic restrictions lead to an energy crisis in injured axons …

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm
and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis …

Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Although neuronal regeneration is a highly energy-demanding process, axonal
mitochondrial transport progressively declines with maturation. Mature neurons typically fail …