In recent years, many compounds having potent antiviral activity in cell culture have been
detected and some of these compounds are currently undergoing either preclinical or …

Many protein ligands bind to heparan sulfate, which results in their presentation, protection,
oligomerization or conformational activation. Binding depends on the pattern of sulfation and …

Pakistan is facing severe economical crunch due to continuously growing gap between
energy demand and supply. The shortage in power and gas supply has already halted many …

Heparan sulfate (HS) is a highly sulfated polysaccharide and is present in large quantities
on the cell surface and in the extracellular matrix. Herpes simplex virus type 1 (HSV-1) …

Heparan sulfate (HS) and its highly modified form, 3-O-sulfated heparan sulfate (3-OS HS),
contribute strongly to herpes simplex virus type-1 (HSV-1) infection in vitro. Here we report …

Herpes simplex virus type 1 (HSV-1) infection of the corneal stroma remains a major cause
of blindness. Primary cultures of corneal fibroblasts (CF) were tested and found susceptible …

Sialic acids and heparan sulfates make up the outermost part of the cell membrane and the
extracellular matrix. Both structures are characterized by being negatively charged, serving …

Heparan sulfate (HS) moieties on cell surfaces are known to provide attachment sites for
many viruses including herpes simplex virus type-1 (HSV-1). Here, we demonstrate that …

Protein sulfoconjugation, or sulfation, represents a critical post-translational modification
(PTM) process that involves the attachment of sulfate groups to various positions of …

Background Memory performance in older persons can reflect genetic influences on
cognitive function and dementing processes. We aimed to identify genetic contributions to …