TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

V Mühlgrabner, T Peters, RMH Velasco Cárdenas… - Science …, 2024 - science.org
Low antigen sensitivity and a gradual loss of effector functions limit the clinical applicability
of chimeric antigen receptor (CAR)–modified T cells and call for alternative antigen receptor …