Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of clinically aggressive
diseases associated with poor outcome. Studies that focus specifically on PTCL are …

Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in
humans, but they are not generally consumed at levels that effect significant change in …

An intriguing aspect of the clinical activity of FMS-like tyrosine kinase 3 inhibitors (FLT3 TKIs)
is their apparent higher activity against peripheral blasts from FLT3/internal tandem …

Variations in tumor biology from patient to patient combined with the low overall survival rate
of hepatocellular carcinoma (HCC) present significant clinical challenges. During the …

Understanding the effects of inflammation and cirrhosis on the regulation of drug metabolism
during the progression of hepatocellular carcinoma (HCC) is critical for developing patient …

The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism
and are responsible for the major part of metabolism of clinically important drugs. The …

Hepatocellular carcinoma (HCC), the most common type of liver cancer, is the second
leading cause of cancer-related mortality worldwide. Processes involved in HCC …

The present paper is an update of the data on the effects of diseases and environmental
factors on the expression and/or activity of human cytochrome P450 (CYP) enzymes and …

Purpose: Compelling evidence supports the presence of P450 enzymes (CYPs) in the
central nervous system (CNS). However, little information is available on the localization and …

Medulloblastomas are among the most frequently diagnosed pediatric solid tumors, and
drug resistance remains as the principal cause of treatment failure. Hypoxia and the …