Nonribosomal peptide synthetases (NRPSs) are large multienzyme machineries that
assemble numerous peptides with large structural and functional diversity. These peptides …

Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

Many Fungi have a well-developed secondary metabolism. The diversity of fungal species
and the diversification of biosynthetic gene clusters underscores a nearly limitless potential …

Background The pathways of thermal instability of amino acids have been unknown. New
mass spectrometric data allow unequivocal quantitative identification of the decomposition …

Transfer RNAs (tRNA) are best known for their role as adaptors during translation of the
genetic code. Beyond their canonical role during protein biosynthesis, tRNAs also perform …

Clostridium scindens biotransforms primary bile acids into secondary bile acids, and is
correlated with inhibition of Clostridium difficile growth in vivo. The aim of the current study …

The period from 1950 to date brought about a revolution in the pharmaceutical industry: the
use of large-scale fermentation methods to produce drugs (mostly antibiotics). The industrial …

Covering: 2000 to up to 2023 α, β-Dehydroamino acids (dhAAs) are unsaturated
nonproteinogenic amino acids found in a wide array of naturally occurring peptidyl …

Cyclodipeptides (CDP) represent a diverse family of small, highly stable, cyclic peptides that
are produced as secondary functional metabolites or side products of protein metabolism by …

Cyclic dipeptides (CDPs) are the simplest form of cyclic peptides with a wide range of
applications from therapeutics to biomaterials. CDP is a versatile molecular platform …