Progressive liver fibrosis, induced by chronic viral and metabolic disorders, leads to more
than one million deaths annually via development of cirrhosis, although no antifibrotic …

99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …

Nanomaterials (NMs) are widely used in commercial and medical products, such as
cosmetics, vaccines, and drug carriers. Exposure to NMs via various routes such as dermal …

Realization of the immense potential of nanomaterials for biomedical applications will
require a thorough understanding of how they interact with cells, tissues, and organs. There …

Hepatocyte resident afflictions continue to affect the human population unabated. The
asialoglycoprotein receptor (ASGPR) is primarily expressed on hepatocytes and minimally …

High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …

The application of nanotechnology in areas of drug delivery and therapy (ie,
nanotherapeutics) is envisioned to have a great impact on public health. The ability of …

Highlights This review focuses on the therapeutic mechanisms, targeting strategies of
various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials …

Mesangial cells-mediated glomerulonephritis is a frequent cause of end-stage renal
disease. Here, we show that celastrol is effective in treating both reversible and irreversible …

With excellent physicochemical properties, inorganic nanomaterials (INMs) have exhibited a
series of attractive applications in biomedical fields. Biological barriers prevent successful …