Autophagy is a conserved process in which the cytosolic materials are degraded and
eventually recycled for cellular metabolism to maintain homeostasis. The dichotomous role …

Simple Summary Osteosarcoma (OS), the most common primary bone tumor, mainly affects
children and adolescents. Unfortunately, in some cases, the absence of response to …

Purpose Breast cancer, the most prevalent cancer worldwide, consists of 4 main subtypes,
namely, Luminal A, Luminal B, HER2-positive, and Triple-negative breast cancer (TNBC) …

Due to the emergence of adjuvant and neoadjuvant chemotherapy, the survival rate has
been greatly improved in osteosarcoma (OS) patients with localized disease. However, this …

Despite advances in diagnostic tools and therapeutic options, treatment resistance remains
a challenge for many cancer patients. Recent studies have found evidence that autophagy …

Current in vitro models for osteosarcoma investigation and drug screening, including two-
dimensional (2D) cell culture and tumour spheroids (ie cancer stem-like cells), lack …

Abstract Ethnopharmacological relevance Polyphyllin D (PD), an active component from
rhizome of Paris polyphylla Sm, root and rhizome, shows a strong anti-cancer activity in …

Osteosarcoma is an aggressive bone cancer that frequently metastasizes to the lungs. The
cytotoxicity of most chemotherapeutics and targeted drugs in the treatment of osteosarcoma …

Chemotherapy is one of the most common therapeutic methods in advanced and metastatic
tumors. Cisplatin (CDDP) is considered as one of the main first-line chemotherapy drugs in …

Acquired chemotherapy resistance is one of the main culprits in the relapse of breast cancer.
But the underlying mechanism of chemotherapy resistance remains elusive. Here, we …