Molecular mechanisms of colon cancer progression and metastasis: recent insights and advancements

A Malki, RA ElRuz, I Gupta, A Allouch, S Vranic… - International journal of …, 2020 - mdpi.com
Colorectal cancer (CRC), the third most common type of cancer, is the second leading cause
of cancer-related mortality rates worldwide. Although modern research was able to shed …

The growing evidence for the importance of the otoliths in spatial memory

PF Smith - Frontiers in neural circuits, 2019 - frontiersin.org
Many studies have demonstrated that vestibular sensory input is important for spatial
learning and memory. However, it has been unclear what contributions the different parts of …

Instrumented swim test for quantifying motor impairment in rodents

NC Hughes, DC Roberts, B Tarchini, KE Cullen - Scientific Reports, 2024 - nature.com
Swim tests are highly effective for identifying vestibular deficits in rodents by offering
significant vestibular motor challenges with reduced proprioceptive input, unlike rotarod and …

Balance beam crossing times are slower after noise exposure in rats

D Bartikofsky, MJ Hertz, DS Bauer… - Frontiers in Integrative …, 2023 - frontiersin.org
Introduction The vestibular system integrates signals related to vision, head position, gravity,
motion, and body position to provide stability during motion through the environment …

Non-nutritive Sweetener Aspartame Disrupts Circadian Behavior and Causes Memory Impairment in Mice

H Bai, X Zuo, C Zhao, S Zhang… - Journal of Agricultural and …, 2024 - ACS Publications
As a non-nutritive sweetener, aspartame is widely used in everyday life. However, its safety
is highly controversial, especially its effects on neurobehavior. We evaluated the effects of …

Genetic and behavioral characterization of a Kmt2d mouse mutant, a new model for Kabuki Syndrome

PK Yamamoto, TA de Souza… - Genes, Brain and …, 2019 - Wiley Online Library
The recessive mutant mice bate palmas (bapa)‐claps in Portuguese arose from N‐ethyl‐N‐
nitrosourea mutagenesis. A single nucleotide, T> C, change in exon 13, leading to a …

Angular vestibuloocular reflex responses in Otop1 mice. I. Otolith sensor input is essential for gravity context-specific adaptation

SI Khan, CC Della Santina… - Journal of …, 2019 - journals.physiology.org
The role of the otoliths in mammals in the angular vestibuloocular reflex (VOR) has been
difficult to determine because there is no surgical technique that can reliably ablate them …

The critical role of vestibular graviception during cognitive-motor development

A Le Gall, P Hilber, C Chesneau, J Bulla… - Behavioural Brain …, 2019 - Elsevier
Earth's gravity acts both as a mechanical stimulus on the body and as a sensory stimulus to
the vestibular organ, which is transmitted into the brain. The vestibular system has been …

Betahistine alleviates benign paroxysmal positional vertigo (BPPV) through inducing production of multiple CTRP family members and activating the ERK1/2-AKT …

J Hui, Q Lei, Z Ji, D Zi - Biological Research, 2022 - Springer
Background Betahistine is a clinical medication for the treatment of benign paroxysmal
positional vertigo (BPPV). Otolin, a secreted glycoprotein with a C-terminal globular domain …

Otoconia structure after short-and long-duration exposure to altered gravity

R Boyle, J Varelas - Journal of the Association for Research in …, 2021 - Springer
Vertebrates use weight-lending otoconia in the inner ear otolith organs to enable detection
of their translation during self or imposed movements and a change in their orientation with …