Epithelial cells display dynamic behaviours, such as rearrangement, movement and shape
changes, particularly during embryonic development and in equivalent processes in adults …

We review the observations and the basic laws describing the essential aspects of collective
motion—being one of the most common and spectacular manifestation of coordinated …

Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …

E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of
individual cells on matrix. However, its contribution to migration of cells through cell-rich …

Dynamics of epithelial monolayers has recently been interpreted in terms of a jamming or
rigidity transition. How cells control such phase transitions is, however, unknown. Here we …

The epithelial to mesenchymal transition (EMT) converts epithelial cells into migratory and
invasive cells and is a fundamental event in morphogenesis. Although its relevance in the …

Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals. By
regulating contact formation and stability, cadherins play a crucial role in tissue …

Collective cell migration requires maintenance of adhesive contacts between adjacent cells,
coordination of polarized cell protrusions, and generation of propulsive traction forces. We …

Embryo development requires biochemical signalling to generate patterns of cell fates and
active mechanical forces to drive tissue shape changes. However, how these processes are …

The mechanical microenvironment is known to influence single-cell migration; however, the
extent to which mechanical cues affect collective migration of adherent cells is not well …