The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Proteogenomics is an area of research at the interface of proteomics and genomics. In this
approach, customized protein sequence databases generated using genomic and …

Transcriptional regulation and posttranscriptional processing underlie many cellular and
organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue …

Determining the full complement of protein-coding genes is a key goal of genome
annotation. The most powerful approach for confirming protein-coding potential is the …

Alternative splicing is commonly believed to be a major source of cellular protein diversity.
However, although many thousands of alternatively spliced transcripts are routinely detected …

Plants, unlike animals, exhibit a very high degree of plasticity in their growth and
development and employ diverse strategies to cope with the variations during diurnal cycles …

Alternative splicing is a critical determinant of genome complexity and, by implication, is
assumed to engender proteomic diversity. This notion has not been experimentally tested in …

Background RNA sequencing has opened new avenues for the study of transcriptome
composition. Significant evidence has accumulated showing that the human transcriptome …

Here, we present APPRIS (http://appris. bioinfo. cnio. es), a database that houses
annotations of human splice isoforms. APPRIS has been designed to provide value to …

The role of alternative splicing is one of the great unanswered questions in cellular biology.
There is strong evidence for alternative splicing at the transcript level, and transcriptomics …