Nuclear export of mRNAs is a crucial step in the regulation of gene expression, linking
transcription in the nucleus to translation in the cytoplasm. Although important components …

The central role of eukaryotic translation initiation factor 4E (eIF4E) in controlling mRNA
translation has been clearly assessed in the last decades. eIF4E function is essential for …

Export of mRNA from the nucleus to the cytoplasm is a critical process for all eukaryotic gene
expression. As mRNA is synthesized, it is packaged with a myriad of RNA‐binding proteins …

We present an integrated approach that predicts and validates novel anti-cancer drug
targets. We first built a classifier that integrates a variety of genomic and systematic datasets …

Lymph node metastasis is one of the most malignant clinical features in patients with
esophageal squamous cell carcinoma (ESCC). Understanding the mechanism of lymph …

The nuclear pore complex (NPC) mediates trafficking between the cytoplasm and
nucleoplasm. It also plays key roles in other nuclear processes such as chromatin silencing …

Cancer is one of the most studied areas of human biology over the past century. Despite
having attracted much attention, hype, and investments, the search to find a cure for cancer …

Viruses have transformed our understanding of mammalian RNA processing, including
facilitating the discovery of the methyl-7-guanosine (m7G) cap on the 5′ end of RNAs. The …

Nuclear mRNA export plays an important role in gene expression. We describe the
mechanisms of mRNA export including the importance of mRNP assembly, docking with the …

Expression of protein-coding genes in eukaryotes relies on the coordinated action of many
sophisticated molecular machineries. Transcription produces precursor mRNAs (pre …