Diabetes is one of the fastest growing diseases worldwide, projected to affect 693 million
adults by 2045. Devastating macrovascular complications (cardiovascular disease) and …

Zinc is a ubiquitous biological metal in all living organisms. The spatiotemporal zinc
dynamics in cells provide crucial cellular signaling opportunities, but also challenges for …

Prime editing enables the installation of virtually any combination of point mutations, small
insertions or small deletions in the DNA of living cells. A prime editing guide RNA (pegRNA) …

Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …

Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

Improved stem cell-derived pancreatic islet (SC-islet) differentiation protocols robustly
generate insulin-secreting β cells from patient induced pluripotent stem cells (iPSCs). These …

Anti-islet autoantibodies serve as key markers in immune-mediated type 1 diabetes (T1D)
and slowly progressive T1D (SPIDDM), also known as latent autoimmune diabetes in adults …

Type 2 diabetes mellitus (T2DM) is an increasingly prevalent multifactorial disease that has
both genetic and environmental risk factors, resulting in impaired glucose homeostasis …

Gut stem cells are accessible by biopsy and propagate robustly in culture, offering an
invaluable resource for autologous cell therapies. Insulin-producing cells can be induced in …