Organs-on-a-chip: a fast track for engineered human tissues in drug development

K Ronaldson-Bouchard, G Vunjak-Novakovic - Cell stem cell, 2018 - cell.com
Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable
modeling of human physiology and disease. The technology has emerged from converging …

Hydrogel based sensors for biomedical applications: An updated review

J Tavakoli, Y Tang - Polymers, 2017 - mdpi.com
Biosensors that detect and convert biological reactions to a measurable signal have gained
much attention in recent years. Between 1950 and 2017, more than 150,000 papers have …

[HTML][HTML] Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices

S Halldorsson, E Lucumi, R Gómez-Sjöberg… - Biosensors and …, 2015 - Elsevier
Culture of cells using various microfluidic devices is becoming more common within
experimental cell biology. At the same time, a technological radiation of microfluidic cell …

Revealing neuronal function through microelectrode array recordings

MEJ Obien, K Deligkaris, T Bullmann… - Frontiers in …, 2015 - frontiersin.org
Microelectrode arrays and microprobes have been widely utilized to measure neuronal
activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate …

[HTML][HTML] Biology-inspired microphysiological system approaches to solve the prediction dilemma of substance testing

U Marx, TB Andersson, A Bahinski, M Beilmann… - Altex, 2016 - ncbi.nlm.nih.gov
The recent advent of microphysiological systems–microfluidic biomimetic devices that aspire
to emulate the biology of human tissues, organs and circulation in vitro–is envisaged to …

Organ‐on‐a‐Chip Systems: microengineering to biomimic living systems

F Zheng, F Fu, Y Cheng, C Wang, Y Zhao, Z Gu - Small, 2016 - Wiley Online Library
“Organ‐on‐a‐chip” systems integrate microengineering, microfluidic technologies, and
biomimetic principles to create key aspects of living organs faithfully, including critical …

Engineering microscale topographies to control the cell–substrate interface

M Nikkhah, F Edalat, S Manoucheri, A Khademhosseini - Biomaterials, 2012 - Elsevier
Cells in their in vivo microenvironment constantly encounter and respond to a multitude of
signals. While the role of biochemical signals has long been appreciated, the importance of …

Cell–material interactions revealed via material techniques of surface patterning

X Yao, R Peng, J Ding - Advanced materials, 2013 - Wiley Online Library
Cell–material interactions constitute a key fundamental topic in biomaterials study. Various
cell cues and matrix cues as well as soluble factors regulate cell behaviors on materials …

Microfluidics for cell-based high throughput screening platforms—A review

G Du, Q Fang, JMJ den Toonder - Analytica chimica acta, 2016 - Elsevier
In the last decades, the basic techniques of microfluidics for the study of cells such as cell
culture, cell separation, and cell lysis, have been well developed. Based on cell handling …

Nanomedicine—challenge and perspectives

K Riehemann, SW Schneider, TA Luger… - Angewandte Chemie …, 2009 - Wiley Online Library
The application of nanotechnology concepts to medicine joins two large cross‐disciplinary
fields with an unprecedented societal and economical potential arising from the natural …