The importance of adenosine for human health cannot be overstated. Indeed, this ubiquitous
nucleoside is an integral component of ATP, and regulates the function of every tissue and …

Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

BACKGROUND: Glaucoma, a leading cause of blindness worldwide, is an optic neuropathy
commonly associated with elevated intraocular pressure (IOP). The major goals of glaucoma …

(N)-Methanocarba adenosine 5′-methyluronamides containing known A3 AR (adenosine
receptor)-enhancing modifications, ie, 2-(arylethynyl) adenine and N 6-methyl or N 6-(3 …

Rhodopsin-like (class A) G protein-coupled receptors (GPCRs) are one of the most
important classes of drug targets. The discovery that these GPCRs can be allosterically …

Cytokinin nucleosides exhibit antitumor, antiviral, antiprotozoal, blood pressure reducing,
anti-inflammatory, and antipsychotic activity. These compounds also influence platelet …

Besides classical G protein coupling, G protein-coupled receptors (GPCRs) are nowadays
well known to show significant signalling via other adaptor proteins, such as β-arrestin2 …

Adenosine receptor activation is involved in myelination and in apoptotic pathways linked to
neurodegenerative diseases. In this study, we investigated the effects of adenosine receptor …

(N)-Methanocarba (bicyclo [3.1. 0] hexane) adenosine derivatives were probed for sites of
charged sulfonate substitution, which precludes diffusion across biological membranes, eg …

The purine nucleoside adenosine is identified as a ubiquitous molecule regulator of different
tissues and cell functions. 1 Adenosine is generated in the extracellular space by the …