The endoplasmic reticulum (ER) functions as a quality-control organelle for protein
homeostasis, or “proteostasis”. The protein quality control systems involve ER-associated …

The pathophysiology of glaucoma is complex, multifactorial and not completely understood.
Elevated intraocular pressure (IOP) and/or impaired retinal blood flow may cause initial optic …

The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …

With the combined purpose of facilitating useful vision over a lifetime, a number of ocular
cells have evolved specialized features not found elsewhere in the body. The trabecular …

The extracellular matrix (ECM) of the trabecular meshwork (TM) is thought to be important in
regulating intraocular pressure (IOP) in both normal and glaucomatous eyes. IOP is …

Current understanding of conventional outflow dysfunction in... : Current Opinion in
Ophthalmology Current understanding of conventional outflow dysfunction in glaucoma …

Purpose: The last decade has witnessed an unprecedented growth in glaucoma treatment
options through the introduction of minimally invasive glaucoma surgeries (MIGS). The aim …

The TGF-β signaling pathway plays a crucial role in several key aspects of development and
tissue homeostasis. TGF-β ligands and their mediators have been shown to be important …

Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor
and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a …

Changes in aqueous humor dynamics with age and in glaucoma have been studied for
several decades. More recently, techniques have been developed which confirm earlier …