Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment

B Moghaddam, D Javitt - Neuropsychopharmacology, 2012 - nature.com
Glutamate is the primary excitatory neurotransmitter in mammalian brain. Disturbances in
glutamate-mediated neurotransmission have been increasingly documented in a range of …

Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma

J Dalmau, E Tüzün, H Wu, J Masjuan… - Annals of …, 2007 - Wiley Online Library
Objective To report the autoantigens of a new category of treatment‐responsive
paraneoplastic encephalitis. Methods Analysis of clinical features, neuropathological …

Diagnosis and management of neuropsychiatric SLE

JG Hanly - Nature Reviews Rheumatology, 2014 - nature.com
Nervous system involvement in systemic lupus erythematosus (SLE) can manifest as a
range of neurological and psychiatric features, which are classified using the ACR case …

Pathogenesis, diagnosis and management of neuropsychiatric SLE manifestations

GK Bertsias, DT Boumpas - Nature Reviews Rheumatology, 2010 - nature.com
Neuropsychiatric events are common in patients with systemic lupus erythematosus (SLE),
but less than one-third of these events can be directly attributed to SLE. Increased …

Human lupus autoantibodies against NMDA receptors mediate cognitive impairment

C Kowal, LA DeGiorgio, JY Lee… - Proceedings of the …, 2006 - National Acad Sciences
Neuropsychiatric systemic lupus erythematosus, which often entails cognitive disturbances
and memory loss, has become a major complication for lupus patients. Previously, we …

Neurologic manifestations of systemic lupus erythematosus in children and adults

E Muscal, RL Brey - Neurologic clinics, 2010 - neurologic.theclinics.com
Among the collagen vascular diseases neurologic manifestations have been most
commonly recognized and well-studied in systemic lupus erythematosus (SLE, lupus) …

A meta-analysis of serum and cerebrospinal fluid autoantibodies in neuropsychiatric systemic lupus erythematosus

RC Ho, C Thiaghu, H Ong, Y Lu, CS Ho, WW Tam… - Autoimmunity …, 2016 - Elsevier
Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most devastating
presentations of SLE and comprises of psychiatric, central and peripheral neurological signs …

B cells move to centre stage: novel opportunities for autoimmune disease treatment

JL Browning - Nature reviews drug discovery, 2006 - nature.com
The B-cell arm of the immune system has long been appreciated for its crucial role in
pathogen resistance, but in the study of many autoimmune diseases, T cells have dominated …