Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

Human pluripotent stem cell (hPSC)-derived neuron cultures have emerged as models of
electrical activity in the human brain. Microelectrode arrays (MEAs) measure changes in the …

The electrophysiological technology having a high spatiotemporal resolution at the single‐
cell level and noninvasive measurements of large areas provide insights on underlying …

Genome-wide association studies (GWASs) have identified hundreds of loci associated with
psychiatric diseases, yet there is a lack of understanding of disease pathophysiology …

In vitro neuronal models have become an important tool to study healthy and diseased
neuronal circuits. The growing interest of neuroscientists to explore the dynamics of …

Background STXBP1-related disorder (STXBP1-RD) is a neurodevelopmental disorder
caused by pathogenic variants in the STXBP1 gene. Its gene product MUNC18-1 organizes …

Gene-targeted therapies for genetic neurodevelopmental disorders (NDDs) are becoming a
reality. The Center for Epilepsy and Neurodevelopmental Disorders (ENDD) is currently …

In situ physiological signals of in vitro neural disease models are essential for studying
pathogenesis and drug screening. Currently, an increasing number of in vitro neural disease …

With the advent of human-induced pluripotent stem cells (hiPSCs) and differentiation
protocols, methods to create in-vitro human-derived neuronal networks have been …

Abstract Syntaxin-binding protein 1 (STXBP1) is a presynaptic protein that plays important
roles in synaptic vesicle docking and fusion. STXBP1 haploinsufficiency causes STXBP1 …