Standard culture-based testing of the susceptibility of Mycobacterium tuberculosis to
pyrazinamide is difficult to perform. This systematic review with meta-analyses evaluated the …

The emergence of multidrug-resistant (MDR)-TB and, more recently, of extensively drug-
resistant (XDR)-TB is a real threat to achieve TB control and elimination. Over 400,000 new …

Ethylene is an important phytohormone that promotes the ripening of fruits and senescence
of flowers thereby reducing their shelf lives. Specific ethylene biosynthesis inhibitors would …

C109 is a potent but poorly soluble FtsZ inhibitor displaying promising activity against
Burkholderia cenocepacia, a high-risk pathogen for cystic fibrosis (CF) sufferers. To harness …

Background. Pyrazinamide (PZA) is essential in tuberculosis treatment. We describe the
prevalence, trends, and predictors of PZA resistance in Mycobacterium tuberculosis complex …

We report herein the synthesis of a new biologically active 3, 4-dihydropyrimidin-2 (1H)-
thione derivative (4) from 9-phenanthrenecarboxaldehyde, thiourea, and methyl …

Our objective was to establish reference MIC quality control (QC) ranges for drug
susceptibility testing of antimycobacterials, including first-line agents, second-line …

The syntheses and investigations of new biologically active derivatives of
dihydropyrimidines by Biginelli reaction in the presence of copper triflate are reported. Due …

Tuberculosis still represents a major public health problem, especially in low-resource
countries where the burden of the disease is more important. Multidrug-resistant and …

Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide
(PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance …