Curving biological membranes establishes the complex architecture of the cell and mediates
membrane traffic to control flux through subcellular compartments. Common molecular …

Membranes are flexible barriers that surround the cell and its compartments. To execute vital
functions such as locomotion or receptor turnover, cells need to control the shapes of their …

LRRK2 is a kinase mutated in Parkinson's disease, but how the protein affects synaptic
function remains enigmatic. We identified LRRK2 as a critical regulator of EndophilinA …

Synucleins and apolipoproteins have been implicated in a number of membrane and lipid
trafficking events. Lipid interaction for both types of proteins is mediated by 11 amino acid …

Research investigating lipid membrane curvature generation and sensing is a rapidly
developing frontier in membrane physical chemistry and biophysics. The fast recent …

Functioning as key players in cellular regulation of membrane curvature, BAR domain
proteins bend bilayers and recruit interaction partners through poorly understood …

There are several examples of membrane-associated protein domains that target curved
membranes. This behavior is believed to have functional significance in a number of …

Short cationic, amphipathic antimicrobial peptides are multi-functional molecules that have
roles in host defense as direct microbicides and modulators of the immune response. While …

Pulsed electron spin resonance (ESR) dipolar spectroscopy (PDS) in combination with site-
directed spin labeling is unique in providing nanometer-range distances and distributions in …

Misfolding and amyloid fibril formation by human islet amyloid polypeptide (hIAPP) are
thought to be important in the pathogenesis of type 2 diabetes, but the structures of the …