Recent biochemical, biophysical, and genetic studies have shown that heparan sulfate, a
major component of the cellular glycocalyx, participates in infection of SARS-CoV-2 by …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

The development of next-generation antimalarials that are efficacious against the human
liver and asexual blood stages is recognized as one of the world's most pressing public …

Highlights•The global prevalence of parasitic protozoan diseases remains a significant
public health challenge.•Halofuginone, a plant-derived compound, has beneficial roles in …

Aminoacyl-tRNA synthetases (aaRSs) are promising drug targets due to their essential roles
in protein translation. Although current inhibitors primarily occupy one or two of the three …

Multiple myeloma (MM) is a plasma cell malignancy characterised by aberrant production of
immunoglobulins requiring survival mechanisms to adapt to proteotoxic stress. We here …

The SARS-CoV-2 Spike glycoprotein (S protein) acquired a unique new 4 amino acid-PRRA-
insertion sequence at amino acid residues (aa) 681–684 that forms a new furin cleavage …

Aminoacyl-tRNA synthetases (aaRSs) are ancient enzymes that serve a foundational role in
the efficient and accurate translation of genetic information from messenger RNA to proteins …

Aminoacyl-tRNA synthetases (aaRSs) are promising antimicrobial targets due to their
essential roles in protein translation, and expanding their inhibitory mechanisms will provide …

Compared with adults, children are less likely infected with SARS-CoV-2 and are often
asymptomatic when infected. However, infection in children can lead to severe disease. The …