Normal hearing depends on sound amplification within the mammalian cochlea. The
amplification, without which the auditory system is effectively deaf, can be traced to the …

High doses of salicylate, the anti-inflammatory component of aspirin, induce transient
tinnitus and hearing loss. Systemic injection of 250 mg/kg of salicylate, a dose that reliably …

The therapeutic efficacy of mesenchymal stem cells (MSCs) in tissue engineering and
regenerative medicine is determined by their unique biological, mechanical, and …

In this study, we investigated the effects of membrane cholesterol content on the mechanical
properties of cell membranes by using optical tweezers. We pulled membrane tethers from …

Protrusions are deformations that form at the surface of living cells during biological activities
such as cell migration. Using combined optical tweezers and fluorescent microscopy, we …

Although high doses of sodium salicylate impair cochlear function, it paradoxically enhances
sound-evoked activity in the auditory cortex (AC) and augments acoustic startle reflex …

Short-term tinnitus develops shortly after the administration of a high dose of salicylate.
Since salicylate selectively potentiates N-methyl-D-aspartate (NMDA) currents in spiral …

Ovarian cancer is the deadliest gynecological cancer in women. It is a highly metastatic
disease with pelvis, regional lymph nodes, and peritoneal cavity as major sites for tumor …

Living cells maintain a huge transmembrane electric field across their membranes. This
electric field exerts a force on the membrane because the membrane surfaces are highly …

Salicylate, a common drug frequently used long term in the clinic, is well known for causing
reversible hearing loss and tinnitus. Our previous study, however, demonstrated that chronic …