Low back pain (LBP) is a major reason for disability, and symptomatic intervertebral disc
(IVD) degeneration (IDD) contributes to roughly 40% of all LBP cases. Current treatment …

Chronic low back pain caused by intervertebral disc (IVD) degeneration, also termed chronic
discogenic low back pain (CD‐LBP), is one of the most prevalent musculoskeletal diseases …

Oxidative stress and aging lead to progressive senescence of nucleus pulposus (NP) cells,
resulting in intervertebral disc (IVD) degeneration (IVDD). In some cases, degenerative IVD …

With the increased burden of low back pain (LBP) in our globally aging population there is a
need to develop preclinical models of LBP that capture clinically relevant features of …

Chronic low back pain is a global socioeconomic crisis and treatments are lacking in part
due to inadequate models. Etiological research suggests that the predominant pathology …

Introduction Intervertebral disc (IVD) degeneration is often associated with low back pain
and radiating leg pain. The purpose of this study is to develop a reproducible and …

In the majority of patients with breast cancer in the advanced stages, skeletal metastases are
common, which may cause excruciating pain. Currently available drug treatments for relief of …

This paper is the fortieth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Back pain is often associated with intervertebral disc (IVD) degeneration, and IVD
degeneration phenotypes are commonly characterized by annulus fibrosus (AF)-driven and …

Globally, the prevalence of chronic pain is high at 10% to 50% of the adult population. 18,
23, 40, 57, 63, 64 Chronic pain not only impairs the quality of life of patients and their …