Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

New discoveries providing insights into mitochondrial bioenergetics, their dynamic
interactions as well as their role in cellular homeostasis have dramatically advanced our …

Pathogenic mutations in mitochondrial DNA (mtDNA) compromise cellular metabolism,
contributing to cellular heterogeneity and disease. Diverse mutations are associated with …

In the field of neurodegenerative diseases, especially sporadic Parkinson's disease (sPD)
with dementia (sPDD), the question of how the disease starts and spreads in the brain …

Mitochondrial abnormalities have been identified as a central mechanism in multiple
neurodegenerative diseases and, therefore, the mitochondria have been explored as a …

How mitochondrial DNA mutations clonally expand in an individual cell is a question that
has perplexed mitochondrial biologists for decades. A growing body of literature indicates …

Mitochondria are the only organelles, along with the nucleus, that have their own DNA.
Mitochondrial DNA (mtDNA) is a double-stranded circular molecule of~ 16.5 kbp that can …

Mitochondrial dysregulation, such as mitochondrial complex I deficiency, increased
oxidative stress, perturbation of mitochondrial dynamics and mitophagy, has long been …

Summary Background Mitochondrial DNA (mtDNA) encodes 37 genes necessary for
synthesizing 13 essential subunits of the oxidative phosphorylation system. mtDNA …

Mitochondrial dysfunction is a central aspect of Parkinson's disease (PD) pathology, yet the
underlying mechanisms are not fully understood. This study investigates the link between α …