Protein post-translational modification (PTM) is a covalent process that occurs in proteins
during or after translation through the addition or removal of one or more functional groups …

Energy demand of neurons in brain that is covered by glucose supply from the blood is
ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …

Glycosylation is one of the most common, and the most complex, forms of post‐translational
modification of proteins. This review serves to highlight the role of protein glycosylation in …

Despite intensive research efforts over the past few decades, the mechanisms underlying
the etiology of sporadic Alzheimer's disease (AD) remain unknown. This fact is of major …

Regional glucose hypometabolism is a defining feature of Alzheimer disease (AD). One
emerging link between glucose hypometabolism and progression of AD is the nutrient …

Alzheimer's disease (AD) is the most common cause of dementia, affecting millions of
people worldwide, and no cure is currently available. The major pathological hallmarks of …

Alzheimer disease (AD) is a growing problem for aging populations worldwide. Despite
significant efforts, no therapeutics are available that stop or slow progression of AD, which …