The importance of nutrition in human health has been understood for over a century.
However, debate is ongoing regarding the role of added and free sugars in physiological …

Insulin synthesis in pancreatic β‐cells is initiated as preproinsulin. Prevailing glucose
concentrations, which oscillate pre‐and postprandially, exert major dynamic variation in …

Objective The objective is to formulate clinical practice guidelines for the treatment of
diabetes in older adults. Conclusions Diabetes, particularly type 2, is becoming more …

More than 25% of the US population aged $65 years has diabetes (1), and the aging of the
overall population is a significant driver of the diabetes epidemic. Although the burden of …

Objective To examine the association between maternal age and a wide range of adverse
pregnancy outcomes after adjustment for confounding factors in obstetric history and …

According to the most recent surveillance data, the prevalence of diabetes among US adults
over age 65 years varies from 22% to 33%, depending on the diagnostic criteria employed …

Importance There is substantial uncertainty about optimal glycemic control in older adults
with type 2 diabetes mellitus. Observations Four large randomized clinical trials (RCTs) …

Diabetes increases the risk of physical dysfunction and disability. Diabetes-related
complications and coexisting morbidities partially explain the deterioration in physical …

Background Glycemic control in diabetes mellitus is a cornerstone in reducing morbidity and
mortality of the disease. Achieving glycemic control or reducing hyperglycemia significantly …

OBJECTIVE—We determined whether reduced insulin sensitivity, mitochondrial dysfunction,
and other age-related dysfunctions are inevitable consequences of aging or secondary to …