Carcinogenic human papillomavirus infection

M Schiffman, J Doorbar, N Wentzensen… - Nature reviews Disease …, 2016 - nature.com
Infections with human papillomavirus (HPV) are common and transmitted by direct contact.
Although the great majority of infections resolve within 2 years, 13 phylogenetically related …

Human papillomavirus molecular biology and disease association

J Doorbar, N Egawa, H Griffin… - Reviews in medical …, 2015 - Wiley Online Library
Human papillomaviruses (HPVs) have evolved over millions of years to propagate
themselves in a range of different animal species including humans. Viruses that have co …

Persistent human papillomavirus infection

AN Della Fera, A Warburton, TL Coursey, S Khurana… - Viruses, 2021 - mdpi.com
Simple Summary The success of HPV as an infectious agent lies not within its ability to
cause disease, but rather in the adeptness of the virus to establish long-term persistent …

The biology and life-cycle of human papillomaviruses

J Doorbar, W Quint, L Banks, IG Bravo, M Stoler… - Vaccine, 2012 - Elsevier
Human papillomaviruses (HPVs) comprise a diverse group, and have different epithelial
tropisms and life-cycle strategies. Many HPVs are classified as low-risk, as they are only …

[HTML][HTML] The low-risk papillomaviruses

N Egawa, J Doorbar - Virus research, 2017 - Elsevier
Human Papillomavirus (HPV) research has been dominated by the study of a subset of
Alpha papillomaviruses that together cause almost 5% of human cancers worldwide, with …

[HTML][HTML] HPV16 E7 genetic conservation is critical to carcinogenesis

L Mirabello, M Yeager, K Yu, GM Clifford, Y Xiao, B Zhu… - Cell, 2017 - cell.com
Although most cervical human papillomavirus type 16 (HPV16) infections become
undetectable within 1–2 years, persistent HPV16 causes half of all cervical cancers. We …

Recurrent YAP1-MAML2 and YAP1-NUTM1 fusions in poroma and porocarcinoma

S Sekine, T Kiyono, E Ryo, R Ogawa… - The Journal of …, 2019 - Am Soc Clin Investig
Poroma is a benign skin tumor exhibiting terminal sweat gland duct differentiation. The
present study aimed to explore the potential role of gene fusions in the tumorigenesis of …

[HTML][HTML] The E1 proteins

M Bergvall, T Melendy, J Archambault - Virology, 2013 - Elsevier
Abstract E1, an ATP-dependent DNA helicase, is the only enzyme encoded by
papillomaviruses (PVs). It is essential for replication and amplification of the viral episome in …

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

J Hatterschide, P Castagnino, HW Kim, SM Sperry… - Elife, 2022 - elifesciences.org
Persistent human papillomavirus (HPV) infection of stratified squamous epithelial cells
causes nearly 5% of cancer cases worldwide. HPV-positive oropharyngeal cancers harbor …

For better or worse: modulation of the host DNA damage response by human papillomavirus

CJ Studstill, CA Moody - Annual review of virology, 2023 - annualreviews.org
High-risk human papillomaviruses (HPVs) are associated with several human cancers.
HPVs are small, DNA viruses that rely on host cell machinery for viral replication. The HPV …