[HTML][HTML] The global burden of multiple chronic conditions: a narrative review

C Hajat, E Stein - Preventive medicine reports, 2018 - Elsevier
Globally, approximately one in three of all adults suffer from multiple chronic conditions
(MCCs). This review provides a comprehensive overview of the resulting epidemiological …

Anti‐nerve growth factor monoclonal antibodies for the control of pain in dogs and cats

M Enomoto, PW Mantyh, J Murrell, JF Innes… - Veterinary …, 2019 - Wiley Online Library
Nerve growth factor (NGF) is essential for the survival of sensory and sympathetic neurons
during development. However, in the adult, NGF and its interaction with tropomyosin …

Elevated dementia risk, cognitive decline, and hippocampal atrophy in multisite chronic pain

W Zhao, L Zhao, X Chang, X Lu… - Proceedings of the …, 2023 - National Acad Sciences
Numerous studies have investigated the impacts of common types of chronic pain (CP) on
patients' cognitive function and observed that CP was associated with later dementia. More …

Physical activity and exercise therapy benefit more than just symptoms and impairments in people with hip and knee osteoarthritis

ST Skou, BK Pedersen, JH Abbott, B Patterson… - Journal of orthopaedic & …, 2018 - jospt.org
Osteoarthritis (OA) of the hip and knee is among the leading causes of global disability,
highlighting the need for early, targeted, and effective treatment. The benefits of exercise …

Association of APOE-ε4, Osteoarthritis, β-Amyloid, and Tau Accumulation in Primary Motor and Somatosensory Regions in Alzheimer Disease

J Du, A Li, D Shi, X Chen, Q Wang, Z Liu, K Sun… - Neurology, 2023 - AAN Enterprises
Background and Objectives One of the most prevalent chronic diseases, osteoarthritis (OA),
may work in conjunction with APOE-ε4 to accelerate Alzheimer disease (AD) alterations …

Association between osteoarthritis and increased risk of dementia: a systemic review and meta-analysis

A Weber, S hung Mak, F Berenbaum, J Sellam… - Medicine, 2019 - journals.lww.com
Objective: To investigate the possible association between osteoarthritis (OA) and the risk of
dementia. Methods: Cohort, case-control, and cross-sectional studies were obtained from …

Causal relationships between osteoarthritis and senile central nerve system dysfunction: A bidirectional two-sample mendelian randomization study

Y Cai, G Zhang, J Liang, Z Jing, R Zhang… - Frontiers in Aging …, 2022 - frontiersin.org
Background The relationship between osteoarthritis (OA) and senile central nervous system
dysfunctions (CNSDs), including Parkinson's disease (PD), Alzheimer's disease (AD), and …

Molecular mechanisms linking osteoarthritis and Alzheimer's disease: shared pathways, mechanisms and breakthrough prospects

IO Umoh, HJ Dos Reis, ACP de Oliveira - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disease mostly affecting the
elderly population. It is characterized by cognitive decline that occurs due to impaired …

Nonpharmacological approaches for pain and symptoms of depression in people with osteoarthritis: systematic review and meta-analyses

CV Burley, AN Casey, MD Jones, KE Wright… - Scientific Reports, 2023 - nature.com
People with osteoarthritis often experience pain and depression. These meta-analyses
examined and compared nonpharmacological randomized controlled trials (RCTs) for pain …

Lysophosphatidylcholines to phosphatidylcholines ratio predicts advanced knee osteoarthritis

W Zhang, G Sun, D Aitken, S Likhodii, M Liu… - …, 2016 - academic.oup.com
Objective. To identify novel biomarker (s) for predicting advanced knee OA. Methods. Study
participants were derived from the Newfoundland Osteoarthritis Study and the Tasmania …