Prostaglandin E2 (PGE2) is the most abundant prostaglandin in the human body. It has a
large number of biological actions that it exerts via four types of receptors, EP1–4. PGE2 is …

Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a
key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are …

Glutathione-S transferase (GST) is a most ancient protein superfamily of multipurpose roles
and evolved principally from gene duplication of an ancestral GSH binding protein. They …

Pathogenic microbes and their hosts have acquired complex signalling mechanisms to
appraise themselves of the environmental milieu in the ongoing battle for survival. Several …

Identifying how genes and their functions evolve after duplication is central to understanding
gene family radiation. In this study, we systematically examined the functional diversification …

Reactive oxygen species (ROS) are at once unsought by-products of metabolism and critical
regulators of multiple intracellular signaling cascades. In nonphotosynthetic eukaryotic cells …

Abstract Background & Aims Nonalcoholic fatty liver disease (NAFLD) has become the most
common chronic liver diseases worldwide. The advantage stage of NAFLD, nonalcoholic …

The mercapturic acid pathway is a major route for the biotransformation of xenobiotic and
endobiotic electrophilic compounds and their metabolites. Mercapturic acids (N-acetyl-l …

За последние 10-15 лет значительно углубились исследования системы глутатиона во
всех основных направлениях. Открыт ряд новых ферментов метаболизма. Многие из …

Abstract Glutathione S-transferases (GSTs), the versatile phase II biotransformation
enzymes, metabolize and detoxify a wide variety of toxic chemical compounds like …