The eukaryotic cell is a bustling collection of macromolecules acting cooperatively to
mediate the functions required for cell viability. Specific, context-dependent and tightly …

The development over the past decade of methods for delivering genes to mammalian cells
has stimulated great interest in the possibility of treating human disease by gene-based …

CRM1 is distantly related to receptors that mediate nuclear protein import and was
previously shown to interact with the nuclear pore complex. Overexpression of CRM1 in …

▪ Abstract The compartmentation of eukaryotic cells requires all nuclear proteins to be
imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and …

High-risk human papillomaviruses (HPVs), including HPV-16 and HPV-18, are the causative
agents of cervical carcinomas and are linked to several other tumors of the anogenital and …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

The cellular target of leptomycin B (LMB), a nuclear export inhibitor, has been identified as
CRM1 (exportin 1), an evolutionarily conserved receptor for the nuclear export signal of …

▪ Abstract The nuclear export of intron-containing HIV-1 RNA is critically dependent on the
activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles …

The human immunodeficiency virus (HIV) genome encodes a total of three structural
proteins, two envelope proteins, three enzymes, and six accessory proteins. Studies over the …

Active nuclear import of protein is controlled by nuclear localization signals (NLSs), but
nuclear export is not understood well. Nuclear trafficking of the catalytic (C) subunit of cAMP …