Gut-liver axis: Pathophysiological concepts and clinical implications

H Tilg, TE Adolph, M Trauner - Cell metabolism, 2022 - cell.com
Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

A pan-cancer mycobiome analysis reveals fungal involvement in gastrointestinal and lung tumors

AB Dohlman, J Klug, M Mesko, IH Gao, SM Lipkin… - Cell, 2022 - cell.com
Fungal microorganisms (mycobiota) comprise a small but immunoreactive component of the
human microbiome, yet little is known about their role in human cancers. Pan-cancer …

[HTML][HTML] The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

F Zhang, D Aschenbrenner, JY Yoo, T Zuo - The Lancet Microbe, 2022 - thelancet.com
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in
humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological …

TH17 cell heterogeneity and its role in tissue inflammation

A Schnell, DR Littman, VK Kuchroo - Nature immunology, 2023 - nature.com
Since their discovery almost two decades ago, interleukin-17-producing CD4+ T cells (TH17
cells) have been implicated in the pathogenesis of multiple autoimmune and inflammatory …

Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis

H He, Q Qin, F Xu, Y Chen, S Rao, C Wang, X Jiang… - Science …, 2023 - science.org
Developing oral nanomedicines that suppress intestinal inflammation while modulating gut
microbiota and brain interactions is essential for effectively treating inflammatory bowel …

Gut–liver axis: barriers and functional circuits

O Pabst, MW Hornef, FG Schaap, V Cerovic… - Nature Reviews …, 2023 - nature.com
The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

[HTML][HTML] Targeting gut microbiota and metabolism as the major probiotic mechanism-An evidence-based review

T Ma, X Shen, X Shi, HA Sakandar, K Quan, Y Li… - Trends in Food Science …, 2023 - Elsevier
Background The human gut hosts complex microbial communities, which are linked to
health and disease. The gut microbiota is continuously reshaped by multiple environmental …

The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

NN Liu, CX Yi, LQ Wei, JA Zhou, T Jiang, CC Hu… - Cancer Cell, 2023 - cell.com
Although polymorphic microbiomes have emerged as hallmarks of cancer, far less is known
about the role of the intratumor mycobiome as living microorganisms in cancer progression …

Fungal microbiota sustains lasting immune activation of neutrophils and their progenitors in severe COVID-19

T Kusakabe, WY Lin, JG Cheong, G Singh… - Nature …, 2023 - nature.com
Gastrointestinal fungal dysbiosis is a hallmark of several diseases marked by systemic
immune activation. Whether persistent pathobiont colonization during immune alterations …