It is widely accepted that senescent cells accumulate with aging. They are characterized by
replicative arrest and the release of a myriad of factors commonly called the senescence …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …

Cardiovascular diseases (CVD) are predominantly an aging disease. Important sex-specific
differences exist and the mechanism (s) by which this sex-by-age interaction influences CVD …

Organoids are tiny, self-organized, three-dimensional tissue cultures that are derived from
the differentiation of stem cells. The growing interest in the use of organoids arises from their …

Myocardial infarction (MI) in humans is a common cause of cardiac injury and results in
irreversible loss of myocardial cells and formation of fibrotic scar tissue. This fibrotic tissue …

Heart failure secondary to cardiomyocyte loss and/or dysfunction is the number one killer
worldwide. The field of myocardial regeneration with its far-reaching primary goal of cardiac …

c-Kit, a type III receptor tyrosine kinase (RTK), is involved in multiple intracellular signaling
whereby it is mainly considered a stem cell factor receptor, which participates in vital …

Over the years strong evidence has been accumulated showing that aerobic physical
exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk …

Cardiomyopathy is a common complication in diabetic patients. Ventricular dysfunction
without coronary atherosclerosis and hypertension is driven by hyperglycemia …

Cardiac remuscularization has been the stated goal of the field of regenerative cardiology
since its inception. Along with the refreshment of lost and dysfunctional cardiac muscle cells …