Looking ahead: visual and anatomical endpoints in future trials of diabetic macular ischemia

CMG Cheung, E Pearce, B Fenner, P Sen, V Chong… - …, 2021 - karger.com
Diabetic macular ischemia (DMI) is a common complication of diabetic retinopathy that can
lead to progressive and irreversible visual loss. Despite substantial clinical burden, there are …

Imaging endpoints for clinical trials in MacTel type 2

D Pauleikhoff, L Pauleikhoff, EY Chew - Eye, 2022 - nature.com
Abstract Introduction Macular Telangiectasia type 2 (MacTel) is a bilateral
neurodegenerative disease associated with dysfunction in the serine and lipid metabolism …

Challenges associated with ellipsoid zone intensity measurements using optical coherence tomography

KE Lee, H Heitkotter, J Carroll - Translational vision science & …, 2021 - tvst.arvojournals.org
Optical coherence tomography (OCT) allows noninvasive visualization of individual retinal
layers and has become a mainstay in the diagnosis and management of a wide range of …

Longitudinal structure-function analysis of molecularly-confirmed CYP4V2 Bietti Crystalline Dystrophy

R Cheloni, N Clough, D Jackson, M Moosajee - Eye, 2024 - nature.com
Abstract Objectives Bietti Crystalline Dystrophy (BCD) is an autosomal recessive
progressive retinal disease caused by mutations in CYP4V2. We have characterised the …

Progression of vascular changes in macular telangiectasia type 2: comparison between SD-OCT and OCT angiography

D Pauleikhoff, F Gunnemann, M Book… - Graefe's Archive for …, 2019 - Springer
Purpose To investigate the different appearances of vascular changes in macular
telangiectasia type 2 (MacTel) and to describe their possible progression, the vascular …

[HTML][HTML] Deep learning-based automatic detection of ellipsoid zone loss in spectral-domain OCT for hydroxychloroquine retinal toxicity screening

T De Silva, G Jayakar, P Grisso, N Hotaling… - Ophthalmology …, 2021 - Elsevier
Purpose Retinal toxicity resulting from hydroxychloroquine use manifests photoreceptor loss
and disruption of the ellipsoid zone (EZ) reflectivity band detectable on spectral-domain (SD) …

Incidence and phenotypical variation of outer retina-associated hyperreflectivity in macular telangiectasia type 2

S Mueller, F Gunnemann, K Rothaus, M Book… - British Journal of …, 2021 - bjo.bmj.com
Background Macular telangiectasia type 2 (MacTel) is a neurodegenerative disease
resulting in photoreceptor loss. Optical coherence tomography (OCT) reveals outer retina …

Photoreceptor assessment in age-related macular degeneration

A Domalpally, AM Haas, S Chandra, B VanderZee… - Eye, 2024 - nature.com
Clinical trials investigating drugs for various stages of age-related macular degeneration
(AMD) are actively underway and there is a strong interest in outcomes that demonstrate a …

One-year follow-up of optical coherence tomography angiography microvascular findings: macular telangiectasia type 2 versus tamoxifen retinopathy

YJ Park, S Lee, YH Yoon - Graefe's Archive for Clinical and Experimental …, 2022 - Springer
Purpose To compare microstructural and microvascular changes in eyes with macular
telangiectasia type 2 (MacTel2) and in those with tamoxifen retinopathy (TR) at baseline and …

Correlation of optical coherence tomography angiography characteristics with visual function to define vision-threatening diabetic macular ischemia

WS Tsai, S Thottarath, S Gurudas, P Sen, E Pearce… - Diagnostics, 2022 - mdpi.com
The thresholds of macular microvasculature parameters associated with mild visual
impairment in diabetic macular ischemia (DMI) patients are unclear. Therefore, this …