Antimicrobial resistance is considered a major public-health issue. Policies recommended
by the World Health Organization (WHO) include research on new antibiotics. No new class …

Actinobacteria exhibit cosmopolitan distribution since their members are widely distributed
in aquatic and terrestrial ecosystems. In the environment they play relevant ecological roles …

Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

Cyclopropane-functionalized hydrocarbons are excellent fuels due their high energy
density. However, the organic synthesis of these molecules is challenging. In this work, we …

Actinobacteria, particularly those of genus Streptomyces, remain invaluable hosts for the
discovery and engineering of natural products and their cognate biosynthetic pathways …

Soil microbiota represent one of the ancient evolutionary origins of antibiotic resistance and
have been proposed as a reservoir of resistance genes available for exchange with clinical …

Bacteria of the order Actinomycetales are one of the most important sources of
pharmacologically active and industrially relevant secondary metabolites. Unfortunately …

Here we report an efficient CRISPR–Cas9 knock-in strategy to activate silent biosynthetic
gene clusters (BGCs) in streptomycetes. We applied this one-step strategy to activate …

Pharmaceutically important polyketides such as avermectin are mainly produced as
secondary metabolites during the stationary phase of growth of Streptomyces species in …

Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …