Enzymatic noncovalent synthesis

H He, W Tan, J Guo, M Yi, AN Shy, B Xu - Chemical reviews, 2020 - ACS Publications
Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

NBD-based synthetic probes for sensing small molecules and proteins: design, sensing mechanisms and biological applications

C Jiang, H Huang, X Kang, L Yang, Z Xi… - Chemical Society …, 2021 - pubs.rsc.org
Compounds with a nitrobenzoxadiazole (NBD) skeleton exhibit prominent useful properties
including environmental sensitivity, high reactivity toward amines and biothiols (including …

Supramolecular biomaterials for cancer immunotherapy

H Liang, Q Lu, J Yang, G Yu - Research, 2023 - spj.science.org
Cancer immunotherapy has achieved tremendous successful clinical results and obtained
historic victories in tumor treatments. However, great limitations associated with feeble …

Dynamic responsiveness of self‐assembling peptide‐based nano‐drug systems

Y Wang, J Zhan, J Huang, X Wang… - Interdisciplinary …, 2023 - Wiley Online Library
Dynamic‐responsive self‐assembly is the process of ordered supramolecular structure
formation or reversible decomposition from building blocks. This process is driven by non …

Recent advances: peptides and self-assembled peptide-nanosystems for antimicrobial therapy and diagnosis

P Zou, WT Chen, T Sun, Y Gao, LL Li, H Wang - Biomaterials Science, 2020 - pubs.rsc.org
Bacterial infections, especially the refractory treatment of drug-resistant bacteria, are one of
the greatest threats to human health. During the past decades, biomedical nanomaterials …

Selective degradation of PD‐L1 in cancer cells by enzyme‐instructed self‐assembly

Y Wang, X Li, D Zheng, Y Chen… - Advanced Functional …, 2021 - Wiley Online Library
Here, a novel strategy to selectively degrade membrane proteins of programmed cell death‐
ligand 1 (PD‐L1) in cancer cells is reported. 4T1 cells show high levels of extracellular …

Self-assembling biomolecules for biosensor applications

J Kim, JH Kang, WH Kwon, I Lee, SJ Park… - Biomaterials …, 2023 - spj.science.org
Molecular self-assembly has received considerable attention in biomedical fields as a
simple and effective method for developing biomolecular nanostructures. Self-assembled …

A supramolecular self-assembled nanomaterial for synergistic therapy of immunosuppressive tumor

T Wang, Z Gao, Y Zhang, Y Hong, Y Tang… - Journal of Controlled …, 2022 - Elsevier
Triple negative breast cancer (TNBC) is an immunosuppressive “cold” tumor that lacks
immune cell infiltration and activation, resulting in a poor response to immune checkpoint …

Triple enzyme‐regulated molecular hydrogels for carrier‐free delivery of lonidamine

C Wu, C Wang, Y Zheng, Y Zheng, Z Liu… - Advanced Functional …, 2021 - Wiley Online Library
Cancerous cells exhibit overexpression of multiple enzymes in various cellular
compartments. These enzymes are often undruggable, yet display unique advantages in …

Peptide Assemblies for Cancer Therapy

Y Qiao, B Xu - ChemMedChem, 2023 - Wiley Online Library
Supramolecular assemblies made by the self‐assembly of peptides are finding an
increasing number of applications in various fields. While the early exploration of peptide …