The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or
ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists …

In hemostasis and thrombosis, the complex process of thrombus formation involves different
molecular pathways of platelet and coagulation activation. These pathways are considered …

Osteonecrosis of the femoral head (ONFH) is a debilitating disease with major social and
economic impacts. It frequently affects relatively young adults and has a predilection for …

Red blood cells (RBCs) and platelets contribute to the coagulation capacity in bleeding and
thrombotic disorders. The thrombin generation (TG) process is considered to reflect the …

Objective: Fibrin is considered to strengthen thrombus formation via integrin αIIbβ3, but
recent findings indicate that fibrin can also act as ligand for platelet glycoprotein VI …

Background: Platelets and neutrophils are the first blood cells accumulating at sites of
arterial thrombus formation, and both cell types contribute to the pathology of thrombotic …

The endothelial regulation of platelet activity is incompletely understood. Here we describe
novel approaches to find molecular pathways implicated on the platelet–endothelium …

The activities of adhesion and signaling receptors in platelets are controlled by several
mechanisms. An important way of regulation is provided by proteolytic cleavage of several of …

Fibrinogen γ'accounts for 3% to 40% of plasma fibrinogen. Earlier studies indicated that
fibrinogen γ'forms altered fibrin clots under static conditions, whereas clinically, altered …