Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis

PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Why senescent cells are resistant to apoptosis: an insight for senolytic development

L Hu, H Li, M Zi, W Li, J Liu, Y Yang, D Zhou… - Frontiers in Cell and …, 2022 - frontiersin.org
Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

TTT Vo, TY Peng, TH Nguyen, TNH Bui… - Cell Communication and …, 2024 - Springer
Copper is a crucial trace element that plays a role in various pathophysiological processes
in the human body. Copper also acts as a transition metal involved in redox reactions …

Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications

Y Zheng, J Sun, Z Luo, Y Li, Y Huang - Cell Death & Disease, 2024 - nature.com
Regulated cell death (RCD) refers to the form of cell death that can be regulated by various
biomacromolecules. Each cell death modalities have their distinct morphological changes …

Distinct photo-oxidation-induced cell death pathways lead to selective killing of human breast cancer cells

AF Dos Santos, A Inague, GS Arini, LF Terra… - Cell death & …, 2020 - nature.com
Lack of effective treatments for aggressive breast cancer is still a major global health
problem. We have previously reported that photodynamic therapy using methylene blue as …

STING dependent BAX-IRF3 signaling results in apoptosis during late-stage Coxiella burnetii infection

M Chauhan, CA Osbron, HS Koehler… - Cell Death & …, 2024 - nature.com
Abstract STING (STimulator of Interferon Genes) is a cytosolic sensor for cyclic dinucleotides
(CDNs) and initiates an innate immune response upon binding to CDNs. Coxiella burnetii is …

[HTML][HTML] alpha-synuclein, autophagy-lysosomal pathway, and Lewy bodies: Mutations, propagation, aggregation, and the formation of inclusions

A Bayati, PS McPherson - Journal of Biological Chemistry, 2024 - Elsevier
Research into the pathophysiology of Parkinson's disease (PD) is a fast-paced pursuit, with
new findings about PD and other synucleinopathies being made each year. The …

Temperature-responsive two-dimensional polydopamine hydrogel: Preparation, mechanisms, and applications in cancer treatment

T Gong, J Jiang, C Chen, Y Lv, T Cao, P Cao… - International Journal of …, 2024 - Elsevier
Temperature-responsive hydrogels are advanced materials that exhibit significant physical
or chemical changes in response to temperature variations. When the temperature reaches …

Insights into the Theranostic Activity of Nonoxido VIV: Lysosome-Targeted Anticancer Metallodrugs

PD Pattanayak, A Banerjee, G Sahu, S Das… - Inorganic …, 2024 - ACS Publications
Developing new anticancer agents can be useful, with the ability to diagnose and treat
cancer worldwide. Previously, we focused on examining the effects of nonoxidovanadium …

[HTML][HTML] Reactive oxygen species (ROS)-mediated oxidative stress in chronic liver diseases and its mitigation by medicinal plants

P Sharma, M Nandave, D Nandave… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Reactive oxygen species (ROS) play a crucial role in cell survival regulation, and its low
levels may act as indicators to encourage cellular proliferation. In contrast, elevated levels of …