During the course of malignant cancer progression, neoplastic cells undergo dynamic and
reversible transitions between multiple phenotypic states, the extremes of which are defined …

MicroRNAs (miRNAs) are a class of posttranscriptional regulators that have recently
introduced an additional level of intricacy to our understanding of gene regulation. There are …

Solid tumours are an enormous cancer burden and a major therapeutic challenge. The
cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

MYC regulates the transcription of thousands of genes required to coordinate a range of
cellular processes, including those essential for proliferation, growth, differentiation …

Translocations that involve the mixed lineage leukaemia (MLL) gene identify a unique group
of acute leukaemias, and often predict a poor prognosis. The MLL gene encodes a DNA …

Self-renewal is the process by which stem cells divide to make more stem cells, perpetuating
the stem cell pool throughout life. Self-renewal is division with maintenance of the …

Comparing independent high-throughput gene-expression experiments can generate
hypotheses about which gene-expression programs are shared between particular …

MicroRNAs (miRNAs) govern an expanding number of biological and disease processes.
Understanding the mechanisms by which the miRNA pathway is regulated, therefore …

Neural stem cells (NSCs) can be experimentally derived or induced from different sources,
and the NSC systems generated so far are promising tools for basic research and …